God's definition of what matters is pretty straight forward. He measures our lives by how we love.
Our greatest fear should not be of failure but of succeeding at things in life that don't really matter.
The world says love yourself, grab all you can, follow your heart. Jesus says deny yourself, grab your cross and follow me.
God doesn't call us to be comfortable. He calls us to trust Him so completely that we are unafraid to put ourselves in situations where we will be in trouble if He doesn't come through.